Protein Modification Reagents
Biotium Clostridium difficile (Toxin A)(253/422), CF740 conjugate, 0.1mg/mL
This MAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation.Primary antibodies are available
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum, 9001-12-1, MFCD00130830, 50 mg
Lyophilized powder (from sterile-filtered solution), 0.5-5.0 FALGPA units/mg solid, cell culture tested, Synonym: Clostridiopeptidase A. This product is suitable for the disaggregation of human tumor, mouse kidney, human adult and fetal brain, lung and many other epithelia tissues. It has also been shown to be effective in liver and kidney perfusion studies, digestion of pancreas, isolation of nonparenchymal rat liver cells and hepatocyte preparation.
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum powder, suitable for cell culture, >=4 FALGPA units/mg solid, high purity, >=700 CDU/mg solid (CDU = collagen digestion units) | 9001-12-1 | MFCD00130830 | 7.5KU
Collagenase from Clostridium histolyticum powder, suitable for cell culture, >=4 FALGPA units/mg solid, high purity, >=700 CDU/mg solid (CDU = collagen digestion units) | 9001-12-1 | MFCD00130830 | 7.5KU
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum Sigma Blend Type H, ≥1.0 FALGPA units/mg solid | 9001-12-1 | MFCD00130830 | 500mg
Collagenase from Clostridium histolyticum Sigma Blend Type H, ≥1.0 FALGPA units/mg solidPurity: MW: | 9001-12-1 | MFCD00130830 | 500mg
